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KMID : 0356919920250050955
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Korean Journal of Anesthesiology
1992 Volume.25 No. 5 p.955 ~ p.961
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The Effect of Intravenous Lidocaine Infusion on SUccinylcholine-or Vecuronium-induced Neuromuscular Blck in the Cats
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갑형식
김명희/이기영/문봉기/김종래/박광원
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Abstract
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The effect of lidocaine on the neuromuscular junction and the interaction between lidocaine and the muscle relaxant, succinylcholine(SCC) or vecuronium(VEC), were investigated in 12 cats of either sex using the sciatic nerve-anterior tibialis
muscle
preparation.
The degree of twitch depression with lidocaine itself was 16.43(14.94%, and the ED50 from dose-response curves of SCC and VEC(8.35(4.62 and 6.36(8.03μg/kg, respectively) in groupⅡ(under lidocaine infusion) were smaller than those(20.57(15.80
and
8.98(7.31μg/kg)in group I(without lidocaine). There was no difference in the duration of action of SCC and VEC between the two groups, but the onset of VEC in group Ⅱ was longer than in group I(n<0.05). The mean arterial pressure(MAP) after
lidocaine
infusion was reduced 149.17 to 130.83mmHg and MAPs at the same dose of each agent were also lower in group Ⅱthan in group I.
The authors conclude that lidocaine itself produces the twitch depression and potentiates the SCC-or VEC-induced neuromuscular block. However, there is no influence on the duration of SCC of VEC.
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KEYWORD
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